簡介：阿洛司他丁，Aloxistatin (E64d)是可滲透細(xì)胞,不可逆的廣譜半胱氨酸蛋白酶 (cysteine protease) 抑制劑。
阿洛司他丁物理化學(xué)性質(zhì)：
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密度 |
1.2±0.1 g/cm3 |
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沸點(diǎn) |
470.5±55.0 °C at 760 mmHg |
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熔點(diǎn) |
126.2°C |
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分子式 |
C17H30N2O5 |
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分子量 |
342.431 |
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閃點(diǎn) |
238.4±31.5 °C |
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精確質(zhì)量 |
342.215485 |
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PSA |
97.03 |
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LogP |
3.64 |
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外觀性狀 |
固體;White to Almost white powder to crystal |
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蒸汽壓 |
0.0±2.6 mmHg at 25°C |
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折射率 |
1.53 |
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儲存條件 |
-20°C冷藏、密閉、干燥處 |
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穩(wěn)定性 |
按規(guī)定使用和貯存的不會分解 |
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水溶解性 |
Soluble in DMSO, DMF or ethanol |
阿洛司他丁詳細(xì)介紹：
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中文名稱： |
阿洛司他丁 |
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中文別名： |
Aloxistatin 抑制劑;E-64d蛋白酶抑制劑,阿洛司他丁;L-反式-環(huán)氧丁二?；?Leu-3-甲基丁胺乙酯;阿洛司他丁;氯苯胺靈;氯普芬;(2S,3S)-3-[[(2S)-4-甲基-1-[(3-甲基丁基)氨基]-1-氧代-2-戊基]氨基甲?；鵠-2-環(huán)氧乙烷甲酸乙酯 |
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英文名稱： |
Aloxistatin |
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英文別名： |
2-Oxiranecarboxylicacid,3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-,ethyl ester, (2S,3S)-;E-64d [for Biochemical Research];E-64d;(2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]-butyl]amino]carbonyl]-2-oxiranecarboxylic acid ethyl ester;2-Oxiranecarboxylicacid,3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbo...;ALLATOSTATIN I;Aloxistatin;E 64d;E-64-d;E-64d (EST,EP 453,NSC 694281, Aloxistatin);EST;L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester;Aloxistatin (E-64d) EST Loxistatin;E64c ethyl ester;ep453;LOXASTATIN;LOXISTATIN;(2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester;Ethyl (2S,3S)-3-[[(2S)-4-Methyl-1-[(3-methylbutyl)amino]-1-oxo-2-pentanyl]carbamoyl]-2-oxiranecarboxylate;(2S,3S)-3-[[(2S)-4-Methyl-1-[(3-methylbutyl)amino]-1-oxo-2-pentanyl]carbamoyl]-2-oxiranecarboxylic Acid Ethyl Ester;Aloxistatine;Aloxistatinum;Aloxistatina;Aloxistatin [INN];E 64c ethyl ester;EST (pharmaceutical);Aloxistatine [French];Aloxistatinum [Latin];Aloxistatina [Spanish];C17H30N2O5;EP 453;E64d;L5W337AOUR;MLS000028372;SMR000058552;Ethyl (+)-(2S,3S)-2,3-epoxy-N-((S)-1-(isopentylcarbamoyl)-3-methylbutyl)succinamate;Oxiranecarb |
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CAS號： |
88321-09-9 |
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分子式： |
C17H30N2O5 |
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分子量： |
342.43 |
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詳細(xì)描述： |
博飛美科提供88321-09-9，阿洛司他丁，E 64d，Medlife，上?，F(xiàn)貨。 Medlife，致力于提供高品質(zhì)、高性價比小分子化合物的產(chǎn)品。 Medlife小分子化合物大量庫存，提供超過2萬種的抑制劑、激動劑、拮抗劑等產(chǎn)品，是藥物及疾病研究的重要原料供應(yīng)商。 半胱氨酸蛋白酶抑制劑，Aloxistatin (E64d) 是可滲透細(xì)胞,不可逆的廣譜半胱氨酸蛋白酶 (cysteine protease) 抑制劑。 查詢關(guān)鍵詞:“88321-09-9，阿洛司他丁，E 64d，PC15607，Medlife，上海現(xiàn)貨”。 |
阿洛司他丁參考文獻(xiàn)：
[1]. Doh-Ura K, et al. Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation. J Virol. 2000 May;74(10):4894-7.
[2]. Konjar S, et al. Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology. 2010 Oct;131(2):257-67.
[3]. Mullins SR, et al. Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins. Biol Chem. 2012 Dec;393(12):1405-16.
[4]. Hook G, et al. The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity. J Alzheimers Dis. 2011;26(2):387-408.
[5]. Cheng XW, et al. Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment. Am J Pathol. 2008 Aug;173(2):358-69.
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